人横纹肌肉瘤细胞株A-204
T细胞株
成纤维细胞株
小鼠Mo-MuLv感染的3T3细胞株
培养基:（FM, Cat. No. 2301）
储存：液氮
运输：干冰
用途：科研
The most abundant cell type in lung interstitium is
fibroblasts. They resemble ordinary fibroblasts but have
some distinguishing features, for example, they have long
branching processes ａnd gap junctions. Their principle
function is production of type III collagen, elastin, ａnd
proteoglycans of the extracellular matrix of the alveolar
septa. Pulmonary fibroblasts （PF） play an important role
in the repair ａnd remodeling processes following injury.
The controlled accumulation of fibroblasts to sites of
inflammation is crucial to effective tissue repair after
injury [1]. Either inadequate or excessive accumulation of
fibroblasts could result in abnormal tissue function. For
example, the excess proliferation of fibroblasts
contributes to the adventitial thickening observed during
the development of hypoxia-induced pulmonary hypertension
[2].
HPF from ScienCell Research Laboratories are isolated from
human lung tissue. HPF are cryopreserved at primary culture
ａnd delivered frozen. Each vial contains >5 x 105 cells in
1 ml volume. HPF are characterized by immunofluorescent
method with antibody to fibronectin. HPF are negative for
HIV-1, HBV, HCV, mycoplasma, bacteria, yeast ａnd fungi.
HPF are guaranteed to further expand for 15 population
doublings at the conditions provided by ScienCell Research
Laboratories.
Reference
[1] Kuwano K, Hagimoto N, Hara N. （2001） Molecular
mechanisms of pulmonary fibrosis ａnd current treatment.
Curr Mol Med 1（5）:551-73.
[2] Das M, Dempsey EC, Reeves JT, Stenmark KR. （2004）
Selective expansion of fibroblast subpopulations from
pulmonary artery adventitia in response to hypoxia. Am J
Physiol Lung Cell Mol Physiol 282（5）:L976-86
