100-39-人肝细胞生长因子

100-39-人肝细胞生长因子,100-39-人肝细胞生长因子,100-39-人肝细胞生长因子
上海逸研生物科技有限公司
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上海逸研生物科技有限公司是一家销售生物化学试剂及实验耗材的公司主营产品：常规生化试剂，抗体，试剂盒，分离试剂，培养基，血清，细胞及实验室耗材，过滤耗材，食品检测耗材，大气监测耗材，汽车检测耗材等。主要代理有：sigma，Roche，thermo，life，abcam，CST，biovision ，vector,sciencell，whatman，millipore，pall，sartorius等，公司成立以来，秉着诚信经营，服务的理念为广大科研客户及公司带来的服务。

100-39-人肝细胞生长因子,100-39-人肝细胞生长因子,100-39-人肝细胞生长因子

Catalog Number:

100-39

Synonyms:

Scatter Factor （SF）, Hepatopoietin （HPTA）

Deion:

HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear 697 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains （α-chain and β-chain） held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues.*Manufactured using （BTI-Tn-5B1-4） cells under license from Boyce Thompson Institute for Plant Research, Inc.

AA Sequence:

alpha chain: QRKRRNTIHE FKKSAKTTLI KIDPALKIKT KKVNTADQCA NRCTRNKGLP FTCKAFVFDK ARKQCLWFPF NSMSSGVKKE FGHEFDLYEN KDYIRNCIIG KGRSYKGTVS ITKSGIKCQP WSSMIPHEHS FLPSSYRGKD LQENYCRNPR GEEGGPWCFT SNPEVRYEVC DIPQCSEVEC MTCNGESYRG LMDHTESGKI CQRWDHQTPH RHKFLPERYP DKGFDDNYCR NPDGQPRPWC YTLDPHTRWE YCAIKTCADN TMNDTDVPLE TTECIQGQGE GYRGTVNTIW NGIPCQRWDS QYPHEHDMTP ENFKCKDLRE NYCRNPDGSE SPWCFTTDPN IRVGYCSQIP NCDMSHGQDC YRGNGKNYMG NLSQTRSGLT CSMWDKNMED LHRHIFWEPD ASKLNENYCR NPDDDAHGPW CYTGNPLIPW DYCPISRCEG DTTPTIVNLD HPVISCAKTK QLR

 

beta chain: VVNGIP TRTNIGWMVS LRYRNKHICG GSLIKESWVL TARQCFPSRD LKDYEAWLGI HDVHGRGDEK CKQVLNVSQL VYGPEGSDLV LMKLARPAVL DDFVSTIDLP NYGCTIPEKT SCSVYGWGYT GLINYDGLLR VAHLYIMGNE KCSQHHRGKV TLNESEICAG AEKIGSGPCE GDYGGPLVCE QHKMRMVLGV IVPGRGCAIP NRPGIFVRVA YYAKWIHKII LTYKVPQS

 

Source:

（BTI‐Tn‐5B1‐4） Hi‐5 Insect cells*

Purity:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

The ED₅₀ was determined by the dose-dependent stimulation of the proliferation of monkey 4MBr-5 cells was found to be in the range of 20.0-40.0 ng/ml.

 

 

 

 

Cross Reactivity:

Dog, Monkey, Mouse, Rabbit, Rat, Human + Mouse, Human, Leech

Research Interests:

	Angiogenesis/ Cardiovascular		Cancer
	Neurobiology		Proliferation
	Stem Cells & Differentiation		Wound Healing

 

 

Country of Origin:

USA

Research Use Only. Not for use in diagnostic or therapeutic procedures.

*Manufactured using （BTI-Tn-5B1-4） cells under license from the Boyce Thompson Institute for Plant Research, Inc.